The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2022

Filed:

Jun. 22, 2018
Applicants:

Systimmune, Inc., Redmond, WA (US);

Sichuan Baili Pharmaceutical Co. Ltd., Chengdu, CN;

Inventors:

Ole Olsen, Everett, WA (US);

Phil Tan, Edmonds, WA (US);

Dong Xia, Redmond, WA (US);

David Jellyman, Duvall, WA (US);

Brian Kovacevich, Snohomish, WA (US);

Bill Brady, Bothell, MA (US);

Blair Renshaw, Renton, WA (US);

Zeren Gao, Redmond, WA (US);

Yi Zhu, Chengdu, CN;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 47/68 (2017.01); C12N 15/85 (2006.01); A61K 9/08 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61K 47/6801 (2017.08); C12N 15/85 (2013.01); A61K 9/08 (2013.01); A61K 45/06 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/76 (2013.01); C12N 2015/8518 (2013.01);
Abstract

The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.


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