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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11535656 B1

PDFFull Text
Date of Patent:
Dec. 27, 2022

Filed:

Mar. 26, 2018

Cytokine combination

Applicant:

Jinyu Zhang, Chongqing, CN;

Inventor:

Jinyu Zhang, Chongqing, CN;

Assignee:

Other;

Attorneys:

Honigman LLP

Thomas A. Wootton, Esq.

Jonathan P. O'Brien

Primary Examiner:

Brian Gangle

Assistant Examiner:

Andrea K McCollum

Int. Cl.
CPC ...
C07K 14/54 (2006.01); A61P 35/00 (2006.01); C07K 14/52 (2006.01); C07K 14/535 (2006.01); C07K 14/55 (2006.01); A61K 38/20 (2006.01); A61K 38/19 (2006.01); A61P 35/04 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5434 (2013.01); A61K 38/193 (2013.01); A61K 38/208 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07K 14/52 (2013.01); C07K 14/535 (2013.01); C07K 14/54 (2013.01); C07K 14/55 (2013.01); A61K 9/0014 (2013.01); A61K 38/00 (2013.01); C07K 14/5418 (2013.01); C07K 14/5443 (2013.01);
Abstract

Provided is a cytokine combination for treating a tumor and/or preventing recurrence or metastasis of the tumor. The cytokine combination comprising at least three cytokines selected from the following groups: IL(interleukin)12 or a functional variant thereof, GMCSF (granulocyte-macrophage colony-stimulating factor) or a functional variant thereof, FLT3L (FMS-like tyrosine kinase 3 ligand) or a functional variant thereof, IL2 or a functional variant thereof, IL15 or a functional variant thereof, IL21 or a functional variant thereof, and IL7 or a functional variant thereof. Also provided is a nucleic acid molecule encoding the cytokine combination and a vector thereof, a cell, a pharmaceutical composition, and a application thereof for the manufacture of a drug for treating the tumor and/or preventing recurrence or metastasis of the tumor.

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