The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Jul. 30, 2018
Jiangsu Ruike Medical Science and Technology Co., Ltd., Jiangsu, CN;
Zhaobo Gao, Zhejiang, CN;
Jianhua Chen, Zhejiang, CN;
Zhidong Wan, Zhejiang, CN;
Dawei He, Zhejiang, CN;
Zengle Zhou, Zhejiang, CN;
Xiaodong Ma, Zhejiang, CN;
Wei Xiang, Zhejiang, CN;
Jingxin Lin, Zhejiang, CN;
Yijiang Mei, Zhejiang, CN;
Abstract
The invention relates to the field of pharmaceutical synthesis, in particular to a preparation method of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivatives and their intermediates. The preparation method is carried out starting from compound Formula A1. In the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivatives, the chirality was constructed by enzymatic method, and the products were prepared with high optical purity. The preparation method can be used to produce the key intermediates of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol of darunavir commercially, which is a very economical route suitable for industrial production.