The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2022

Filed:

May. 25, 2017
Applicants:

Evox Therapeutics Ltd., Oxford, GB;

Oxford University Innovation Limited, Oxford, GB;

Inventors:

Justin Hean, Oxford, GB;

Imre Mager, Oxford, GB;

Matthew Wood, Oxford, GB;

Samir El Andaloussi, Huddinge, SE;

Oscar Wiklander, Solna, SE;

Joel Nordin, Stockholm, SE;

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 47/65 (2017.01); A61K 41/00 (2020.01); A61K 47/64 (2017.01); A61K 47/00 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0008 (2013.01); A61K 9/127 (2013.01); A61K 41/0042 (2013.01); A61K 47/00 (2013.01); A61K 47/6425 (2017.08); A61K 47/65 (2017.08); A61K 48/005 (2013.01); A61K 48/0091 (2013.01);
Abstract

The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.


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Hean, Justin. (2022). Exosomes comprising therapeutic polypeptides (U.S. Patent No. 11534499). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11534499

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