The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Jun. 09, 2017
Applicants:
Fudan University, Shanghai, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Shanghai Miracogen Inc., Shanghai, CN;
Inventors:
Ke Yu, Shanghai, CN;
Jingkang Shen, Shanghai, CN;
Tao Meng, Shanghai, CN;
Lanping Ma, Shanghai, CN;
Xuesai Zhang, Shanghai, CN;
Qingrou Li, Shanghai, CN;
Qing Lin, Shanghai, CN;
Assignees:
FUDAN UNIVERSITY, Shanghai, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;
SHANGHAI MIRACOGEN INC., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/36 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 31/537 (2006.01); A61K 47/54 (2017.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/5365 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 31/40 (2013.01); A61K 31/4025 (2013.01); A61K 31/537 (2013.01); A61K 31/5365 (2013.01); A61K 47/542 (2017.08); A61K 47/545 (2017.08); A61K 47/68 (2017.08); A61K 47/6843 (2017.08); A61P 35/00 (2018.01); C07K 16/36 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/90 (2013.01);
Abstract
A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.