The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
May. 16, 2019
Alkermes, Inc., Waltham, MA (US);
Demetri T. Moustakas, Belmont, MA (US);
Mark N. Namchuk, Arlington, MA (US);
Heather C. Losey, Lexington, MA (US);
Juan C. Alvarez, Lincoln, MA (US);
ALKERMES, INC., Waltham, MA (US);
Abstract
The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as 'scIL-10' polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1:(first monomer subunit)-LINKER-(second monomer subunit)   Formula 1wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.