The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2022

Filed:

Nov. 14, 2017
Applicants:

Fred Hutchinson Cancer Center, Seattle, WA (US);

University of Washington, Seattle, WA (US);

Inventors:

Aude G. Chapuis, Seattle, WA (US);

Paul T. Nghiem, Redmond, WA (US);

Megan S. McAfee, Seattle, WA (US);

Natalie J. Miller, Seattle, WA (US);

Kelly Garneski Paulson, Shoreline, WA (US);

David Martin Koelle, Seattle, WA (US);

Thomas M. Schmitt, Seattle, WA (US);

Candice Church, Seattle, WA (US);

Assignees:

FRED HUTCHINSON CANCER CENTER, Seattle, WA (US);

UNIVERSITY OF WASHINGTON, Seattle, WA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61K 38/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01);
Abstract

The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.


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