The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Nov. 04, 2019
Zhejiang University, Hangzhou, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
Abstract
The present invention provides a use of canagliflozin in preparation of an antitumor drug, especially in preparation of a drug for treating solid tumors. It has been proven through researches that canagliflozin has a significant down-regulation effect on immune checkpoint protein PD-L1 in various tumor cells and can effectively enhance the killing effect of T cells on tumor cells in a co-incubation model of T cells and tumor cells, thereby broadening a clinical application scope of the chemical drug canagliflozin in tumor immunotherapy. The present invention provides a new medical use of canagliflozin, and also provides new approaches and potential targets for the development of small molecular drugs based on PD-L1.