The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2022

Filed:

Jul. 31, 2018
Applicant:

Scynexis, Inc., Jersey City, NJ (US);

Inventor:

David A. Angulo Gonzalez, Palmetto Bay, FL (US);

Assignee:

Scynexis, Inc., Jersey City, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4409 (2006.01); A61P 15/02 (2006.01); A61P 31/10 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4409 (2013.01); A61K 9/0014 (2013.01); A61K 9/0053 (2013.01); A61P 15/02 (2018.01); A61P 31/10 (2018.01);
Abstract

Enfumafungin derivative triterpenoid antifungal compounds are used to treat or prevent fungal infections occurring in or under acidic conditions where the pH is lower than about 7, due to their unexpected, enhanced efficacy under such conditions. The enfumafungin derivative triterpenoids (or pharmaceutically acceptable salts or hydrates thereof) are inhibitors of (1,3)-β-D-glucan synthesis and are useful in the treatment or prevention of yeast or mold infections that occur in anatomic areas having a low pH, such as the vaginal cavity, or under acidic local environment conditions such of those seen in fungal abscesses, empyema, or upper gastrointestinal tract infections.


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