The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Sep. 05, 2018
Applicant:
University Court of the University of Edinburgh, Edinburgh Midlothian, GB;
Inventor:
Peter Simmonds, Edinburgh, GB;
Assignee:
UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, Edinburgh Midlothian, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/19 (2006.01); C12N 15/86 (2006.01); A23K 20/174 (2016.01); A23K 20/24 (2016.01); A23L 7/117 (2016.01); A23L 33/16 (2016.01); A23L 33/15 (2016.01); A61K 9/00 (2006.01); A61K 31/14 (2006.01); A61K 31/519 (2006.01); A61K 31/714 (2006.01); A61K 33/26 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/19 (2013.01); A23K 20/174 (2016.05); A23K 20/24 (2016.05); A23L 7/117 (2016.08); A23L 33/15 (2016.08); A23L 33/16 (2016.08); A61K 9/00 (2013.01); A61K 31/14 (2013.01); A61K 31/519 (2013.01); A61K 31/714 (2013.01); A61K 33/26 (2013.01); A61K 45/06 (2013.01); C12N 15/86 (2013.01); A23V 2002/00 (2013.01); C12N 2760/00043 (2013.01); C12N 2760/00051 (2013.01); C12N 2760/16143 (2013.01); C12N 2770/00043 (2013.01); C12N 2770/00051 (2013.01); C12N 2770/32043 (2013.01);
Abstract
The present invention relates to methods and compositions for enhancing expression from RNA expression vectores. The invention is based upon the observation that reducing the frequency of the dinucleotide CpG and UpA has a significant effect on expression from such vectores. Aspects of the invention include, amongst others, synthetic RNA vectores, virions, cells, methods of producing vaccines and methods of treatment or immunisation.