The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Apr. 23, 2019
Taiwan Liposome Co., Ltd., Taipei, TW;
Tlc Biopharmaceuticals, Inc., South San Francisco, CA (US);
Keelung Hong, South San Francisco, CA (US);
Jonathan Fang, South San Francisco, CA (US);
Yu-Cheng Tseng, Taipei, TW;
Ting-Yu Cheng, Taipei, TW;
Wan-Ni Yu, Taipei, TW;
Jo-Hsin Tang, Taipei, TW;
INSPIRMED CORP., Taipei, TW;
Abstract
Provided is a liposomal sustained-release composition for use in treatment of pulmonary disease. The liposomal sustained release composition comprises a liposome that includes a polyethylene glycol (PEG)-modified lipid and encapsulates a tyrosine kinase inhibitor. Tyrosine kinase inhibitor is stably entrapped in the liposome, and the resulting liposomal drug formulation can be aerosolized or nebulized for administration via inhalation. This aerosolized liposomal drug formulation yields consistent pharmacokinetic and pharmacodynamic profiles while achieving desired efficacy and safety.