The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Sep. 06, 2018
Children's National Medical Center, Washington, DC (US);
University of Maryland, College Park, College Park, MD (US);
Alexander I. Son, Washington, DC (US);
Kazue Hashimoto-Torii, Bethesda, MD (US);
Masaaki Torii, Bethesda, MD (US);
Paul D. Morton, Silver Spring, MD (US);
Seiji Ishii, North Bethesda, MD (US);
Justin Opfermann, Washington, DC (US);
Judy Liu, Washington, DC (US);
John Fisher, Kensington, MD (US);
Marco Santoro, Silver Spring, MD (US);
Peter C.W. Kim, Washington, DC (US);
CHILDREN'S NATIONAL MEDICAL CENTER, Washington, DC (US);
UNIVERSITY OF MARYLAND, COLLEGE PARK, College Park, MD (US);
Abstract
Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interia or void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.