The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2022
Filed:
Apr. 26, 2016
Applicant:
Autolus Limited, London, GB;
Inventors:
Martin Pulé, London, GB;
Shaun Cordoba, London, GB;
Assignee:
AUTOLUS LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/86 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/70521 (2013.01); C07K 14/70596 (2013.01); C07K 16/2803 (2013.01); C12N 15/85 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C07K 2319/04 (2013.01); C07K 2319/06 (2013.01); C07K 2319/33 (2013.01); C07K 2319/50 (2013.01);
Abstract
The present invention provides a nucleic acid construct comprising the following structure: A-X-B in which A and B are nucleic acid sequences encoding a first and a second polypeptide of interest (POI); and X is a nucleic acid sequence which encodes a cleavage site, wherein either the first or second POI is a transmembrane protein which comprises an intracellular retention signal.