The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2022
Filed:
Mar. 13, 2017
University of Massachusetts, Boston, MA (US);
The Governing Council of the University of Toronto, Toronto, CA;
Erik J. Sontheimer, Auburndale, MA (US);
Alan Davidson, Toronto, CA;
Karen Maxwell, Toronto, CA;
April Pawluk, Cambridge, MA (US);
Yan Zhang, Ann Arbor, MI (US);
Jooyoung Lee, Worcester, MA (US);
Nadia Amrani, Shrewsbury, MA (US);
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, Toronto, CA;
Abstract
The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.