The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2022
Filed:
Apr. 20, 2017
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Robert Babb, River Edge, NJ (US);
Darya Burakov, Tarrytown, NY (US);
Gang Chen, Yorktown Heights, NY (US);
James P. Fandl, LaGrangeville, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C07K 16/46 (2006.01); C12N 15/85 (2006.01); C12N 15/90 (2006.01); C12Q 1/6897 (2018.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 16/00 (2013.01); C12N 15/85 (2013.01); C12N 15/902 (2013.01); C12Q 1/6897 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/526 (2013.01); C07K 2317/565 (2013.01);
Abstract
This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antibodies including bispecifc antibodies in eukaryotic cells, particularly Chinese hamster () cell lines, by employing an expression-enhancing locus.