The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2022
Filed:
Jan. 16, 2019
Applicant:
Argenx Bv, Ghent, BE;
Inventors:
Luc Van Rompaey, Ghent, BE;
Mahan Moshir, Zwijnaarde, BE;
Tim Delahaye, Zwijnaarde, BE;
Piotr Zabrocki, Zwijnaarde, BE;
Assignee:
argenx BV, Ghent, BE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 35/02 (2006.01); A61K 9/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2875 (2013.01); A61K 9/0019 (2013.01); A61P 35/02 (2018.01); C07K 16/2803 (2013.01); C07K 16/2866 (2013.01); A61K 2039/507 (2013.01); C07K 2317/22 (2013.01); C07K 2317/55 (2013.01);
Abstract
The present invention relates to combination therapies for the treatment of malignancy, particularly myeloid malignancy such as acute myeloid leukemia (AML). The combination therapies may include an antibody molecule that binds to CD70 and at least one antibody molecule that binds to a leukemic stem cell target. Preferred leukemic stem cell targets are TIM-3, IL1R3/IL1RAP and CD47.