The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2022
Filed:
Jun. 05, 2018
Applicant:
Relinia, Inc., Euless, TX (US);
Inventors:
David C Foster, Euless, TX (US);
Lutz B Giebel, San Mateo, CA (US);
Leonard G Presta, San Francisco, CA (US);
Assignee:
RELINIA, INC., Euless, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 14/525 (2006.01); C07K 19/00 (2006.01); A61K 39/00 (2006.01); A61P 29/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/525 (2013.01); A61P 29/00 (2018.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); C07K 16/46 (2013.01); C07K 19/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01);
Abstract
This invention provides for a fusion protein between a single chain TNFR2 Selective Agonist protein (scTNFR2 Selective Agonist) and a dimerization domain, such as an IgGFc protein. The single chain TNFR2 Selective Agonist moiety provides a therapeutic activity by selectively activating the TNFR2 form of the TNF-α receptor, thus selectively stimulating Tregs and/or increasing myelin deposition.