The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 20, 2022

Filed:

Oct. 15, 2020
Applicant:

Novartis Ag, Basel, CH;

Inventors:

Guillaume Barbe, Milton, MA (US);

Gregory Raymond Bebernitz, Tupper Lake, NY (US);

Sicong Geng, Shanghai, CN;

Hatice Belgin Gulgeze Efthymiou, Lynn, MA (US);

Lv Liao, Shanghai, CN;

Fupeng Ma, Melrose, MA (US);

Ruowei Mo, New Hope, PA (US);

David Thomas Parker, Windham, NH (US);

Yunshan Peng, Arlington, MA (US);

Stefan Peukert, Arlington, MA (US);

Nichola Smith, Burlington, MA (US);

Ken Yamada, Brookline, MA (US);

Kayo Yasoshima, Cambridge, MA (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 9/00 (2006.01); A61P 9/06 (2006.01); C07D 471/04 (2006.01); A61K 31/4375 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); C07F 9/6561 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/4375 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); A61P 9/06 (2018.01); C07F 9/6561 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R, R-R, Xand Xare as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.


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