The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 20, 2022

Filed:

Nov. 09, 2020
Applicant:

Glycom A/s, Hørsholm, DK;

Inventors:

Emma Elison, Hjärup, SE;

Bruce McConnell, La Tour de Peilz, CH;

Thierry Hennet, Otelfingen, CH;

Louise Kristine Vigsnæs, København, DK;

Assignee:

Glycom A/S, Hørsholm, DK;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/702 (2006.01); A61K 31/7012 (2006.01); A61K 31/7004 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/702 (2013.01); A61K 9/0053 (2013.01); A61K 31/7004 (2013.01); A61K 31/7012 (2013.01);
Abstract

A method for treating metabolic disorders in non-infant includes administering to an obese non-infant human during a treatment period an effective amount of a mixture of two or more synthetic neutral human milk oligosaccharides (HMOs) selected from 2'-fucosyllactose (2′FL), 3-fucosyllactose (3-FL), difucosyllactose (DFL), lacto-N-fucopentaose I (LNFP-I), lacto-N-tetraose (LNT), and lacto-N-neotetraose (LNnT), and optionally one or more excipients. The method further includes increasing in the gastrointestinal microbiota of the non-infant human during the treatment period, the relative abundance ofand reducing in the non-infant human during the treatment period, a precursor condition for a metabolic disorder associated with development of one or more of obesity-induced pre-diabetes and type 2 diabetes, the precursor condition selected from gut permeability, metabolic endotoxemia, low-grade metabolic inflammation, and body fat percentage.


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