The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 20, 2022

Filed:

Mar. 28, 2018
Applicant:

Agency for Science, Technology and Research, Singapore, SG;

Inventors:

Eun Ju Park, Singapore, SG;

Alexander M. Van Herk, Singapore, SG;

Praveen Thoniyot, Singapore, SG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 8/11 (2006.01); A61K 8/25 (2006.01); A61Q 19/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5192 (2013.01); A61K 8/11 (2013.01); A61K 8/25 (2013.01); A61K 9/5115 (2013.01); A61Q 19/00 (2013.01); A61K 2800/413 (2013.01);
Abstract

There is provided a method of preparing silica nanocapsules, the method comprising mixing a surfactant with water at a temperature that is above the gel-to-liquid transition temperature of the surfactant to form a mixture, passing the mixture one or more times through at least one pore to obtain a dispersion of vesicles, and adding a silica precursor to the dispersion of vesicles to form silica nanocapsules. Also provided is a silica nanocapsule formed from a vesicle template, and a method of delivering one or more types of molecules to a subject. In a specific embodiment, hollow silica nanocapsules having substantially lens-shaped are synthesized by employing dimethyldioctadecylammonium bromide (DODAB) or dioctadecyldimethyl ammonium chloride (DODAC) as the vesicle template and tetraethyl orthosilicate (TEOS) as the silica precursor.


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