The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2022
Filed:
Sep. 06, 2017
Applicants:
The Children's Medical Center Corporation, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Linda Thuy Vo, Pacifica, CA (US);
George Q. Daley, Weston, MA (US);
Assignees:
THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/0783 (2010.01); C12N 15/85 (2006.01); A01K 67/027 (2006.01); C12N 5/0781 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A01K 67/0271 (2013.01); C12N 5/0635 (2013.01); C12N 15/85 (2013.01); C12N 2501/065 (2013.01); C12N 2501/42 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2501/608 (2013.01); C12N 2501/65 (2013.01); C12N 2506/11 (2013.01); C12N 2506/45 (2013.01);
Abstract
Embodiments disclosed here are production methods and compositions of engineered immune cells, such as B or T lymphocytes, from limited lineage myeloid progenitor cells, or from pluripotent stem cells, or from multilineage hematopoietic progenitor cells comprising the addition of various cell differentiation transcription factors and inhibiting epigenetic histone methylations in said cells.