The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 13, 2022

Filed:

Jan. 24, 2020
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Dasa Lipovsek, Pepperell, MA (US);

Joseph Toth, Belmont, MA (US);

Ginger C. Rakestraw, Somerville, MA (US);

Irvith M. Carvajal, Somerville, MA (US);

Stanley Richard Krystek, Jr., Ringoes, NJ (US);

Steven R. O'Neil, Wayland, MA (US);

Guodong Chen, East Brunswick, NJ (US);

Richard Y. Huang, Bridgewater, NJ (US);

Bryan C. Barnhart, San Francisco, CA (US);

John Thomas Loffredo, Yardley, PA (US);

Christina Terragni, Wilmington, MA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/78 (2006.01); A61K 47/64 (2017.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61K 47/6435 (2017.08); G01N 33/6872 (2013.01); A61K 38/00 (2013.01);
Abstract

Provided herein are polypeptides which include tenth fibronectin type III domains (Fn3) that bind to glypican-3. Also provided are fusion molecules comprising aFn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3Fn3 drug conjugates are also provided.


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