The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2022
Filed:
Mar. 28, 2019
Agios Pharmaceuticals, Inc., Cambridge, MA (US);
Zenon D. Konteatis, Chatham, NJ (US);
Mingzong Li, Medford, MA (US);
Peng Liu, Cambridge, MA (US);
Matthew Medeiros, Cambridge, MA (US);
Samuel K. Reznik, Cambridge, MA (US);
Zhihua Sui, Cambridge, MA (US);
Jeremy M. Travins, Southborough, MA (US);
Janeta Popovici-Muller, Windham, NH (US);
Shubao Zhou, Shanghai, CN;
Guangning Ma, Shanghai, CN;
SERVIER PHARMACEUTICALS LLC, Boston, MA (US);
Abstract
The present disclosure provides for compounds according to Formula I or Formula II and their pharmaceutically acceptable salts, stereoisomers, and/or tautomers thereof. Also provided are pharmaceutical compositions and the compounds of formulae I and II for use in methods of treating cancers, via inhibition of MAT2A, including some cancers in which the gene encoding methylthioadenosine phosphorylase (MTAP) is deleted and/or not fully functioning.