The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2022
Filed:
Nov. 12, 2020
Astrazeneca Ab, Sodertalje, SE;
Sam Butterworth, Macclesfield, GB;
Maurice Raymond Verschoyle Finlay, Macclesfield, GB;
Richard Andrew Ward, Macclesfield, GB;
Heather Marie Redfearn, Macclesfield, GB;
Vasantha Krishna Kadambar, Bangalore, IN;
Chandrasekhara Reddy Chintakuntla, Bangalore, IN;
Andiappan Murugan, Bangalore, IN;
Claudio Edmundo Chuaqui, Waltham, MA (US);
AstraZeneca AB, Sodertalje, SE;
Abstract
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.