The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2022
Filed:
Nov. 15, 2018
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Baylor College of Medicine, Houston, TX (US);
Sri Krishna, North Bethesda, MD (US);
Marshall Posner, Mount Vernon, NY (US);
Andrew Sikora, Houston, TX (US);
Karen Anderson, Scottsdale, AZ (US);
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US);
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
BAYLOR COLLEGE OF MEDICINE, Houston, TX (US);
Abstract
Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.