The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2022
Filed:
May. 26, 2020
Applicant:
Children's Hospital Los Angeles, Los Angeles, CA (US);
Inventors:
Mark R. Frey, Glendale, CA (US);
Michael Schumacher, Glendale, CA (US);
Assignee:
Children's Hospital Los Angeles, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61P 11/08 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 1/00 (2006.01); A61K 38/18 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1883 (2013.01); A61P 3/10 (2018.01); A61P 9/10 (2018.01); A61P 11/08 (2018.01); A61P 1/00 (2018.01); G01N 33/5005 (2013.01); G01N 33/6893 (2013.01);
Abstract
Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.