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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11524000 B1

PDFFull Text
Date of Patent:
Dec. 13, 2022

Filed:

Oct. 23, 2018

Targeting mcl-1 to enhance dna replication stress sensitivity for cancer therapy

Applicant:

Emory University, Atlanta, GA (US);

Inventors:

Xingming Deng, Atlanta, GA (US);

Guo Chen, Atlanta, GA (US);

Abu Syed Md Anisuzzaman, Atlanta, GA (US);

Assignee:

Emory University, Atlanta, GA (US);

Attorney:

Emory Patent Group

Primary Examiner:

Taofiq A Solola

Int. Cl.
CPC ...
A61K 31/343 (2006.01); A61P 35/00 (2006.01); A61K 31/15 (2006.01); A61K 31/17 (2006.01); A61K 31/502 (2006.01); A61K 31/517 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/343 (2013.01); A61K 31/15 (2013.01); A61K 31/17 (2013.01); A61K 31/502 (2013.01); A61K 31/517 (2013.01); A61P 35/00 (2018.01); A61K 45/06 (2013.01);
Abstract

This disclosure relates to inhibitors of Mcl-1 stimulated homologous recombination (HR) DNA repair and uses for treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an inhibitor of Mcl-1 in combination with other anti-cancer agents, e.g., that induce DNA replication stress. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering compounds disclosed herein in combination with hydroxyurea, olaparib, or combinations thereof.

Find Patent Forward Citations

Deng, Xingming. (2022). Targeting mcl-1 to enhance dna replication stress sensitivity for cancer therapy (U.S. Patent No. 11524000). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11524000

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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