The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Jun. 03, 2020
Jellox Biotech Inc., Hsinchu, TW;
Ann-Shyn Chiang, Hsinchu, TW;
Dah-Tsyr Chang, Hsinchu, TW;
Jia-Ling Yang, Hsinchu, TW;
Yen-Yin Lin, Hsinchu, TW;
Yu-Chieh Lin, Hsinchu, TW;
Other;
Abstract
Provided is a method for analyzing a tissue specimen, including treating a tissue specimen with an aqueous clearing agent and with at least two fluorescent probes to obtain a cleared and labeled tissue specimen; imaging the cleared and labeled tissue specimen to generate a three-dimensional (3D) image of the tissue specimen; preparing a stained tissue section from the cleared and labeled tissue specimen; capturing a reference two-dimensional (2D) image of the stained tissue section; matching the reference 2D image with the 3D image to extract from the 3D image a series of 2D image slices including a corresponding 2D image slice that corresponds to the reference 2D image; and determining at least one pathological score for each of the series of 2D image slices and reporting the presence or absence and the extent of the disease based on the pathological scores. The method can improve the accuracy of histopathologic diagnosis.