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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11519903 B1

PDFFull Text
Date of Patent:
Dec. 06, 2022

Filed:

Jul. 12, 2017

Compositions and methods of cell attachment

Applicant:

Emulate Inc., Boston, MA (US);

Inventors:

Daniel Levner, Brookline, MA (US);

Kyung Jin Jang, Andover, MA (US);

Jacob Fraser, Somerville, MA (US);

S. Jordan Kerns, Reading, MA (US);

Antonio Varone, West Roxbury, MA (US);

Dongeun Huh, Philadelphia, PA (US);

Assignee:

EMULATE, INC., Boston, MA (US);

Attorney:

Medlen & Carroll, LLP

Primary Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 38/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); G01N 33/50 (2006.01); C07K 14/78 (2006.01); C12N 5/071 (2010.01); C12M 3/06 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
G01N 33/5032 (2013.01); C07K 2/00 (2013.01); C07K 14/78 (2013.01); C12M 23/16 (2013.01); C12M 23/20 (2013.01); C12M 25/02 (2013.01); C12N 5/0018 (2013.01); C12N 5/0068 (2013.01); C12N 5/067 (2013.01); C12N 5/0658 (2013.01); G01N 33/5014 (2013.01); C12N 2500/32 (2013.01); C12N 2521/00 (2013.01); C12N 2533/30 (2013.01); C12N 2533/50 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01); C12N 2533/90 (2013.01); C12N 2535/10 (2013.01); C12N 2537/10 (2013.01); G01N 33/5044 (2013.01);
Abstract

Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

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