The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 06, 2022

Filed:

Aug. 24, 2020
Applicant:

Illumina, Inc., San Diego, CA (US);

Inventors:

AmirAli Hajhossein Talasaz, Menlo Park, CA (US);

Gordon M. Cann, San Francisco, CA (US);

Assignee:

Illumina, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6874 (2018.01); C12Q 1/6869 (2018.01); G16B 25/00 (2019.01); G16B 30/00 (2019.01); C12Q 1/6827 (2018.01); G16B 30/10 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6874 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6869 (2013.01); G16B 25/00 (2019.02); G16B 30/00 (2019.02); G16B 30/10 (2019.02);
Abstract

Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.


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