The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Jan. 08, 2018
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Michael P. Czech, Westborough, MA (US);
Yuefei Shen, Millbury, MA (US);
Assignee:
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/90 (2006.01); C12N 15/113 (2010.01); C12N 9/22 (2006.01); C12N 9/96 (2006.01); A61K 47/64 (2017.01); A61K 47/54 (2017.01); A61P 3/04 (2006.01); A01K 67/027 (2006.01); A61K 9/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); A01K 67/0278 (2013.01); A61K 9/0019 (2013.01); A61K 47/549 (2017.08); A61K 47/64 (2017.08); A61P 3/04 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/003 (2013.01); C07K 14/4702 (2013.01); C12N 5/0653 (2013.01); C12N 9/22 (2013.01); C12N 9/96 (2013.01); C12N 15/113 (2013.01); A01K 2207/12 (2013.01); A01K 2217/07 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0362 (2013.01);
Abstract
Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided.