The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Mar. 19, 2019
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Charleen Hunt, Dumont, NJ (US);
Suzanne Hartford, Putnam Valley, NY (US);
Guochun Gong, Pleasantville, NY (US);
Brian Zambrowicz, Sleepy Hollow, NY (US);
Assignee:
Regeneran Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/86 (2006.01); C12N 15/90 (2006.01); C12N 15/113 (2010.01); C12N 9/22 (2006.01); A01K 67/027 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8509 (2013.01); A01K 67/0275 (2013.01); C12N 9/22 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); C12N 15/907 (2013.01); A01K 2217/07 (2013.01); A01K 2217/072 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0306 (2013.01); A01K 2267/0362 (2013.01); C12N 2015/8527 (2013.01); C12N 2310/20 (2017.05); C12N 2310/531 (2013.01); C12N 2320/11 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/30 (2013.01); C12N 2830/008 (2013.01);
Abstract
Non-human animal cells and non-human animals comprising CRISPR/Cas synergistic activation mediator system components and methods of making and using such non-human animal cells and non-human animals are provided. Methods are provided for using such non-human animals to increase expression of target genes in vivo and to assess CRISPR/Cas synergistic activation mediator systems for the ability to increase expression of target genes in vivo.