The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Aug. 19, 2019
Trican Biotechnology Co., Ltd, New Taipei, TW;
Huang-Tsu Chen, Cupertino, CA (US);
Jiun-Shyang Leou, Hsinchu, TW;
Chung-Yuan Hsu, Kaohsiung, TW;
Cheng-Ke Li, Taoyuan, TW;
Yun-Ting Wang, New Taipei, TW;
Li-Tsen Lin, New Taipei, TW;
TRICAN BIOTECHNOLOGY CO., LTD, New Taipei, TW;
Abstract
The present invention provides a bi-functional fusion protein, (AT)a-Fc-(VT)b, simultaneously targeting vascular endothelial growth factor (VEGF) and angiopoietins (ANGs), wherein AT is an ANG binding motif; and VT is a VEGF binding motif, Fragment crystallizable region (Fc) is an N-terminal of Immunoglobulin G (IgG); each of a and b is an integer from 1 to 10. The bi-functional fusion proteins contain two or more domains of human proteins and are of all human sequences, and thus are expected to be non-immunogenic, and potentially can be used therapeutically in human targeting angiogenesis-associated diseases.