The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
May. 08, 2018
Shanghai Jmt-bio Technology Co., Ltd., Shanghai, CN;
Liping Song, Shanghai, CN;
Xiaotian Cui, Shanghai, CN;
Jian Wang, Shanghai, CN;
Haixiang Wu, Shanghai, CN;
Jiana Jia, Shanghai, CN;
Yi Fan, Shanghai, CN;
Ganliang Zhang, Shanghai, CN;
Tao Li, Shanghai, CN;
Hong Xu, Shanghai, CN;
Yisha She, Shanghai, CN;
Kai Long, Shanghai, CN;
SHANGHAI JMT-BIO TECHNOLOGY CO., LTD., Shanghai, CN;
Abstract
Provided is a bispecific recombinant protein, comprising a high affinity tumor-targeting arm and a low affinity fusion protein blocking the interaction of CD47 with SIRPα. The antibody corresponding to the high affinity tumor-targeting arm does not bind to CD47, and its binding affinity to the target antigen on the tumor cell is at least 6 times as great as the binding affinity of monomer fusion protein homodimer corresponding to the low affinity fusion protein blocking the interaction of CD47 with SIRPα, to a CD47 on the tumor cell, wherein the low affinity fusion protein blocking the interaction of CD47 with SIRPα comprises a SIRPα extracellular truncation. Also provided are nucleic acid molecules encoding recombinant proteins and the use of the recombinant proteins and nucleic acid molecules in the manufacture of a medicament for treating tumors.