The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 06, 2022

Filed:

Dec. 14, 2017
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Patricia K Donahoe, Boston, MA (US);

David Pepin, Somerville, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/575 (2006.01); A61K 38/00 (2006.01); A61K 45/06 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/575 (2013.01); C12N 7/00 (2013.01); A61K 38/00 (2013.01); A61K 45/06 (2013.01); C07K 2319/43 (2013.01); C07K 2319/50 (2013.01); C12N 2750/14143 (2013.01);
Abstract

One aspect of the invention provides a method of ovarian protection by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). Ovarian protection can be an induced arrest of folliculogenesis to preserve fertility. In some embodiments, ovarian protection is oncoprotection, the protection of the ovarian function during a cytotoxic treatment, e.g., chemotherapy. Another aspect of the invention relates to a method of treating PCOS, the method comprising administering to a female subject a composition comprising recombinant MIS protein.


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