The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Jun. 30, 2021
Barry P. Rosen, Boynton Beach, FL (US);
Masafumi Yoshinaga, Doral, FL (US);
Stanislaw F. Wnuk, Miami, FL (US);
MD Abu Hasan Howlader, Miami, FL (US);
SK MD Sazzad Hossain Suzol, Philadelphia, PA (US);
Barry P. Rosen, Boynton Beach, FL (US);
Masafumi Yoshinaga, Doral, FL (US);
Stanislaw F. Wnuk, Miami, FL (US);
Md Abu Hasan Howlader, Miami, FL (US);
Sk Md Sazzad Hossain Suzol, Philadelphia, PA (US);
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, Miami, FL (US);
Abstract
The subject invention provides methods for the chemical synthesis of racemic arsinothricin (D,L-AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl-protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of the resulting sodium salt of trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsNl) was utilized to purify L-AST from racemic AST. This expedient chemical synthesis of AST provides a source of this novel antibiotic for future drug development.