The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Aug. 05, 2019
Applicant:
Purdue Research Foundation, West Lafayette, IN (US);
Inventors:
Mingji Dai, West Lafayette, IN (US);
Dexter Cameron Davis, West Lafayette, IN (US);
Alexander Adibekian, Palm, FL (US);
Dominic Gregor Hoch, Jupiter, FL (US);
Zhong-Yin Zhang, West Lafayette, IN (US);
Assignees:
Purdue Research Foundation, West Lafayette, IN (US);
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 493/10 (2006.01);
U.S. Cl.
CPC ...
C07D 493/10 (2013.01);
Abstract
The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.