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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11518726 B1

PDFFull Text
Date of Patent:
Dec. 06, 2022

Filed:

Oct. 10, 2018

Synthesis of bicyclo[2.2.2]octane derivatives

Applicant:

Eastman Chemical Company, Kingsport, TN (US);

Inventors:

Yue Rachel Hu, Kingsport, TN (US);

Robert Thomas Hembre, Johnson City, TN (US);

Gerald Charles Tustin, Kingsport, TN (US);

Zhufang Liu, Kingsport, TN (US);

Steven J. Adams, Gray, TN (US);

Assignee:

Eastman Chemical Company, Kingsport, TN (US);

Attorneys:

C. Stuart Everett

Tammye L. Taylor Polk

Primary Examiner:

Amy C Bonaparte

Int. Cl.
CPC ...
C07C 29/60 (2006.01); C07C 45/50 (2006.01); C07C 51/16 (2006.01); C07C 67/36 (2006.01); C07C 209/16 (2006.01); C07C 231/02 (2006.01); C07C 263/10 (2006.01); C07C 29/48 (2006.01); C07C 69/013 (2006.01); C07C 51/12 (2006.01); C07C 61/13 (2006.01); C07C 31/27 (2006.01); C07C 211/19 (2006.01); C07C 215/20 (2006.01); C07C 213/02 (2006.01);
U.S. Cl.
CPC ...
C07C 29/60 (2013.01); C07C 29/48 (2013.01); C07C 31/278 (2013.01); C07C 45/50 (2013.01); C07C 51/12 (2013.01); C07C 51/16 (2013.01); C07C 61/13 (2013.01); C07C 67/36 (2013.01); C07C 69/013 (2013.01); C07C 209/16 (2013.01); C07C 211/19 (2013.01); C07C 213/02 (2013.01); C07C 215/20 (2013.01); C07C 231/02 (2013.01); C07C 263/10 (2013.01); C07C 2602/44 (2017.05);
Abstract

Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.

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