The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2022
Filed:
Apr. 07, 2022
Myeloid Therapeutics, Inc., Cambridge, MA (US);
Samuel C. Wagner, San Diego, CA (US);
Thomas E. Ichim, San Francisco, CA (US);
Julia S. Szymanski, San Diego, CA (US);
Santosh Kesari, San Diego, CA (US);
Amit N. Patel, Salt Lake City, UT (US);
Boris Minev, San Diego, CA (US);
Myeloid Therapeutics, Inc., Cambridge, MA (US);
Abstract
The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.