The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 06, 2022

Filed:

Oct. 25, 2017
Applicant:

Catalent U.k. Swindon Zydis Limited, Swindon, GB;

Inventors:

Leon Paul Grother, Swindon, GB;

Keiko Tsutsumi, Swindon, GB;

Rosaleen Theresa McLaughlin, Swindon, GB;

Yik Teng Wong, Swindon, GB;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/19 (2006.01); A61K 9/20 (2006.01); A61K 47/26 (2006.01); A61K 47/42 (2017.01); A61K 31/137 (2006.01); A61K 31/138 (2006.01);
U.S. Cl.
CPC ...
A61K 9/2095 (2013.01); A61K 9/19 (2013.01); A61K 9/2086 (2013.01); A61K 31/137 (2013.01); A61K 31/138 (2013.01); A61K 47/26 (2013.01); A61K 47/42 (2013.01);
Abstract

Described herein is a method for forming multi-layer drug dosage forms having at least two layers. In the method, a first formulation comprising a non-gelling matrix forming agent and having a first density is dosed into a preformed mold. A second formulation comprising a non-gelling matrix former and having a second density not equal to the first density is subsequently dosed into the preformed mold. Then, the combination of the formulations dosed into the mold is freeze dried to form the multi-layer dosage form having at least two layers. The use of a density difference between the first and second formulations ensures formation of a product with two distinct layers.


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