The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 29, 2022

Filed:

Oct. 06, 2017
Applicant:

Omniseq, Inc., Buffalo, NY (US);

Inventors:

Carl Morrison, Fredonia, NY (US);

Sarabjot Pabla, Buffalo, NY (US);

Jeffrey Conroy, Williamsville, NY (US);

Mary Nesline, Buffalo, NY (US);

Mark Gardner, Clarence, NY (US);

Ji He, North Potomac, MD (US);

Sean Glenn, East Amherst, NY (US);

Assignee:

OMNISEQ, INC., Buffalo, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16B 40/00 (2019.01); G16B 5/00 (2019.01); G16B 20/00 (2019.01); G01N 33/574 (2006.01); C07K 16/28 (2006.01); C12Q 1/6886 (2018.01); G16B 20/20 (2019.01); G16B 5/20 (2019.01); G16B 20/40 (2019.01); A61K 39/00 (2006.01); G16H 15/00 (2018.01); G16H 50/20 (2018.01);
U.S. Cl.
CPC ...
G16B 40/00 (2019.02); C07K 16/2818 (2013.01); C12Q 1/6886 (2013.01); G01N 33/574 (2013.01); G01N 33/57484 (2013.01); G16B 5/00 (2019.02); G16B 5/20 (2019.02); G16B 20/00 (2019.02); G16B 20/20 (2019.02); G16B 20/40 (2019.02); A61K 2039/505 (2013.01); A61K 2039/55 (2013.01); C12Q 2600/156 (2013.01); G16H 15/00 (2018.01); G16H 50/20 (2018.01);
Abstract

A method for generating an immune score, the method comprising the steps of: (i) determining a qualitative and/or quantitative assessment of tumor infiltrating lymphocytes in a sample; (ii) determining a qualitative and/or quantitative assessment of T-cell receptor signaling in the sample; (iii) determining a qualitative and/or quantitative assessment of mutation burden in the sample; (iv) generating, using a predictive algorithm, an immune score based on the determined qualitative and/or quantitative assessment of tumor infiltrating lymphocytes, the determined qualitative and/or quantitative assessment of T-cell receptor signaling, and the determined qualitative and/or quantitative assessment of mutation burden.


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