The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Jan. 25, 2017
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Ho Young Lee, South San Francisco, CA (US);
Guoying Jiang, South San Francisco, CA (US);
Pin Yee Wong, South San Francisco, CA (US);
Kendall Carey, South San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); G01N 33/68 (2006.01); C12Q 1/66 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); C12N 9/38 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6854 (2013.01); C07K 16/2803 (2013.01); C07K 16/2809 (2013.01); C07K 16/2863 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C12N 9/2471 (2013.01); C12Q 1/66 (2013.01); C12Y 301/03001 (2013.01); C12Y 305/02006 (2013.01); G01N 33/505 (2013.01); G01N 33/574 (2013.01); C07K 2317/31 (2013.01);
Abstract
The present invention provides a cell-based assay for measuring T cell activation mediated by a T cell-dependent bispecific antibody (TDB). In some aspects, the assay is useful for detecting a TDB in a composition, quantitating the amount of TDB in a composition, determining the potency and/or specificity of a TDB, or determining if a population of cells expresses a target antigen. Compositions and kits are also contemplated.