The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Mar. 25, 2019
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Christian Klein, Schlieren, CH;
Maud Léa Mayoux, Schlieren, CH;
Andreas Roller, Basel, CH;
Wei Xu, Schlieren, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/563 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57407 (2013.01); G01N 33/563 (2013.01);
Abstract
The invention is concerned with a method of predicting response to a PD-1 axis inhibitor such as anti-PD-L1 antibody by determining the abundance of dendritic cells (DCs) in a tumor tissue sample. The abundance of DCs characterized by enhanced expressions of XCR1, IRF8, BATF3 and FLT3 predicts clinical response to the PD-L1 blockade 5 treatment.