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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11512316 B1

PDFFull Text
Date of Patent:
Nov. 29, 2022

Filed:

Jun. 14, 2018

Enhanced organogenesis through manipulation of lin28/let-7/dis3l2

Applicant:

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

George Q. Daley, Cambridge, MA (US);

Alena V. Yermalovich, Cambridge, MA (US);

Jihan K. Osborne, Brighton, MA (US);

Assignee:

Children's Medical Center Corporation, Boston, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Dana H Shin

Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61P 13/12 (2006.01); A61K 9/00 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 9/0034 (2013.01); A61K 38/1709 (2013.01); A61P 13/12 (2018.01); A61K 48/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract

Described herein are methods of prolonging or reactivating organogenesis in a subject in need thereof (e.g., a subject that has impaired organ function such as a prematurely born infant). The methods comprise increasing the expression or activity of Lin28A or Lin28B proteins, inhibiting the expression or activity of let-7 family microRNAs, and/or inhibiting the expression or activity of Dis3L2 exonuclease.

Find Patent Forward Citations

Daley, George. (2022). Enhanced organogenesis through manipulation of lin28/let-7/dis3l2 (U.S. Patent No. 11512316). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11512316

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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