The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Mar. 21, 2019
Applicant:
Duke University, Durham, NC (US);
Inventors:
Conrad Hodgkinson, Durham, NC (US);
Victor Dzau, Durham, NC (US);
Jaewoo Lee, Durham, NC (US);
Bruce A. Sullenger, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C12N 5/077 (2010.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); A61K 31/713 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/531 (2013.01); C12N 2501/65 (2013.01); C12N 2501/999 (2013.01);
Abstract
Disclosed herein are compositions and methods for cellular reprogramming. The compositions comprise one or more miRs and an activator of NFκB. Also provided are methods for enhancing or upregulating cardiomyocyte maturation in a cell or a subject and methods for inhibiting or downregulating cardiomyocyte maturation.