The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Jun. 15, 2018
Applicant:
Sangamo Therapeutics, Inc., Richmond, CA (US);
Inventors:
Anthony Conway, Richmond, CA (US);
Sumiti Jain, Richmond, CA (US);
Gary K. Lee, Richmond, CA (US);
David Paschon, Richmond, CA (US);
Edward J. Rebar, Richmond, CA (US);
Lei Zhang, Richmond, CA (US);
Assignee:
Sangamo Therapeutics, Inc., Brisbane, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C12N 5/0789 (2010.01); C07K 19/00 (2006.01); C07K 14/00 (2006.01); A61K 38/46 (2006.01); C12N 5/0783 (2010.01); C12N 15/85 (2006.01); C07K 14/725 (2006.01); A61P 37/06 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 15/90 (2006.01); C07K 14/74 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 48/0066 (2013.01); A61P 35/00 (2018.01); A61P 37/06 (2018.01); C07K 14/7051 (2013.01); C12N 9/22 (2013.01); C12N 15/8509 (2013.01); C12N 15/907 (2013.01); A61K 48/005 (2013.01); C07K 14/70539 (2013.01); C12N 2015/8518 (2013.01); C12N 2501/515 (2013.01); C12N 2510/00 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Disclosed herein are methods and compositions for inactivating TCR and/or HLA genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and/or cells comprising nucleases are also provided.