The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Oct. 27, 2018
Applicant:
Ossianix, Inc., Philadelphia, PA (US);
Inventors:
Pawel Stocki, Royston, GB;
Krzysztof Bartlomiej Wicher, Cambridge, GB;
Jaroslaw Michal Szary, Stevenage, GB;
Julia Lynn Rutkowski, Bryn Mawr, PA (US);
Assignee:
Ossianix, Inc., Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/2881 (2013.01); A61K 47/6849 (2017.08); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01);
Abstract
The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to improved TfR-binding moieties based on shark VNARs capable of crossing the blood brain barrier (BBB) and capable of carrying and releasing cargo specifically targeted to the parenchymal tissue of the brain.