The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Aug. 21, 2020
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Aaron P. Yamniuk, Lawrenceville, NJ (US);
Stanley R. Krystek, Ringoes, NJ (US);
Assignee:
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C07K 14/78 (2006.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); C12N 15/00 (2013.01); C12N 2320/00 (2013.01); C12N 2330/31 (2013.01);
Abstract
Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.