The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2022
Filed:
Jun. 18, 2020
Arvinas Operations, Inc., New Haven, CT (US);
Yale University, New Haven, CT (US);
Andrew P. Crew, Guilford, CT (US);
Craig M. Crews, New Haven, CT (US);
Xin Chen, Trumbull, CT (US);
Hanqing Dong, Madison, CT (US);
Caterina Ferraro, Stamford, CT (US);
Yimin Qian, Plainsboro, NJ (US);
Kam Siu, Milford, CT (US);
Jing Wang, Milford, CT (US);
Meizhong Jin, East Northport, NY (US);
Michael Berlin, Flemington, NJ (US);
Kurt Zimmermann, Durham, CT (US);
Arvinas Operations, Inc., New Haven, CT (US);
Yale University, New Haven, CT (US);
Abstract
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.