The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 29, 2022

Filed:

Jan. 09, 2020
Applicant:

The Trustees of Princeton University, Princeton, NJ (US);

Inventors:

David W. C. MacMillan, Princeton, NJ (US);

Zhiwei Zuo, Plainsboro, NJ (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 17/363 (2006.01); C07C 211/27 (2006.01); C07C 269/06 (2006.01); C07C 29/00 (2006.01); C07C 29/62 (2006.01); C07C 319/20 (2006.01); C07C 41/22 (2006.01); C07C 45/65 (2006.01); C07D 207/06 (2006.01); C07D 207/08 (2006.01); C07D 209/14 (2006.01); C07D 211/08 (2006.01); C07D 265/30 (2006.01); C07D 295/023 (2006.01); C07D 307/12 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); C07C 17/363 (2013.01); C07C 29/00 (2013.01); C07C 29/62 (2013.01); C07C 41/22 (2013.01); C07C 45/65 (2013.01); C07C 211/27 (2013.01); C07C 269/06 (2013.01); C07C 319/20 (2013.01); C07D 207/06 (2013.01); C07D 207/08 (2013.01); C07D 209/14 (2013.01); C07D 211/08 (2013.01); C07D 265/30 (2013.01); C07D 295/023 (2013.01); C07D 307/12 (2013.01); C07D 401/04 (2013.01); C07C 2601/02 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2602/08 (2017.05); C07C 2602/10 (2017.05);
Abstract

Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. For example, methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.


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